The parish church of Llandderfel (Saint Dervel) is part of the diocese of St Asaph and is mentioned in the Papal Registers of the late 15th century. The poet Dewi Havhesp is buried at Llandderfel church yard.
Palé Hall, on the opposite bank of the Dee, was built in 1871, on the site of an older manor house in Llandderfel. It was designed by Samuel Pountey Smith of Shrewsbury for Henry Robertson MP, a railway engineer and local landowner. The house was used as a military hospital in World War I and a home for evacuated children in World War II. The Robertson family sold the estate to the Duke of Westminster in the 1950s. 
The village was formerly served by the Llandderfel railway station.
- J. A. Twemlow (editor) (1933). "Lateran Regesta 586: 1463". Calendar of Papal Registers Relating to Great Britain and Ireland, Volume 12: 1458-1471. Institute of Historical Research. http://www.british-history.ac.uk/report.aspx?compid=103854&strquery=llandderfel. Retrieved 2 July 2013.
- "Llandderfel". Savills. http://search.savills.com/property-detail/gbwmrstes110050.
- Location map: 52°55’19"N, 3°30’58"W